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Diazepam se ne sme primenjivati kao jedini lek u terapiji depresije ili anksioznosti udružene sa depresijom, jer kod ovih pacijenata može da se izazove suicid.Predloženi mehanizam interakcije je kompetitivno vezivanje teofilina za adenozinske receptore u mozgu. Na taj način onemogućava se farmakodinamsko dejstvo diazepama, dolazi do npr. smanj